A new study on sucralose, a popular sugar-free sweetener that underwent 110 safety studies before the U.S. Food and Drug Administration approved it in 1998—finds the popular ingredient has toxicities that regulatory agencies must consider. New health and safety findings revealed in the study show sucralose, sometimes sold under the brand name Splenda, is “genotoxic,” meaning it breaks up DNA.... 

Many people use artificial sweeteners or sugar substitutes because they think they are cutting calorie intake and will lose weight. Volume 1 of the Encyclopedia of Food Chemistry identified five non-nutritive sweeteners approved by the Food and Drug Administration as GRAS, or generally recognized as safe: acesulfame-K or ace-K, aspartame, neotame, saccharin and sucralose. But studies have shown that...